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29, 30, 31 The drug concentration ranges used were: BSO, 0400 M and L-PAM, 050 M (clinically achievable levels)

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An increase in H 2 O 2 , the presence of other reactive species, or interference with the GSH redox cycle can result in an increase in oxidized glutathione (GSSG)

It also plays a role in maintaining nerve cells and constructing DNA

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Recent advancements have shed light on the complex mechanisms underlying IC and expanded the therapeutic landscape with promising new treatment modalities