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The analysis of variance (Supplementary Table S2) indicates that both pressure and temperature had a significant effect, as well as their interaction ( p 0.05), making it suitable for predicting future supercritical fluid extraction (SFE) yield values

As a result, high-quality Real-World Data (RWD) and Real-World Evidence (RWE) are expected to play an increasingly important role in complementing clinical trial findings and supporting more informed, patient-centered healthcare decisions throughout the product lifecycle