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This mechanism is critical in acetaminophen overdose, where the toxic metabolite NAPQI depletes hepatic glutathione N-acetylcysteine administration replenishes GSH and prevents liver failure

Sedeek M, Hebert RL, Kennedy CR, Burns KD, Touyz RM

Carroll RC, Beattie EC, von Zastrow M, Malenka RC

(1991) The relationship between nuclear glutathione levels and resistance to melphalan in human ovarian tumour cells

This cellular-level shift is why antioxidant support is a foundational strategy for those learning how to live with long-term COVID and manage debilitating post-exertional malaise