They can scratch the skin and increase sensitivity over time
D.AlsopR
Many 2D monolayer cultures have provided foundational data essential for hypothesis building in the field
Removal of a large, thick CMN that leaves a large, dense scar may be acceptable
Guidance such as the ADA/EASD Management of hyperglycaemia in type 2 diabetes consensus report (Davies et al, 2022) recommends early initiation of GLP-1 RAs or SGLT2 inhibitors along with metformin in those with established or high risk of cardiovascular disease, and it is usual practice to titrate one drug up fully before adding the second class, without waiting for further glycaemic assessment
To put it in context, for somebody whose ideal healthy bodyweight is 170 but is starting out at 260, they would, in theory, get down to 221 on semaglutide, 208 on tirzepatide, and 197 on retatrutide, a faster pace of weight loss