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Klinische Studien haben mit dem GIP/GLP-1-Rezeptor-Koagonisten Tirzepatid bei Menschen mit Adipositas, aber ohne Diabetes mellitus eine Gewichtsabnahme um durchschnittlich 20,9 % bei Behandlung ber 72 Wochen mit der hchsten Dosis (15 mg/Woche) beschrieben (57)

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Binding of tastants to their cognate receptors increase intracellular calcium level ([Ca2+]i) which activates transient receptor potential cation channel subfamily M member 5 (TRPM5), a Ca2+/Na+ cotransporter [34]