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Activation of serine/threonine kinase cascade stimulates serine phosphorylation of IRS that in turn impairs tyrosine phosphorylation thus possibly enhancing IRS degradation [144], resulting to alteration of glucose uptake signalling pathways by GLUT4 via IRS-1 and phosphatidylinositol 3-kinase (PI3K)/Akt [137]

IGF-1 LR3 is widely used in vitro to explore cell growth, survival, and differentiation , particularly in skeletal muscle, fibroblast, and neuronal models

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Journal of Neuroscience 24, 1101-1112CrossRefGoogle ScholarPubMed 101Vargas, M.R., Pehar, M., Cassina, P

My goal is to understand the molecular events that have to occur for the in vivo formation of each disulfide bond in folding proteins