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They can be a reasonable supportive adjunct within a program, and they can correct genuine nutrient deficiencies

Particular concerns exist for those with: Type 2 diabetes or pre-diabetes , due to opposing and unpredictable glycaemic effects Cardiovascular disease , given the potential for heart rate changes and fluid retention associated with GH Active malignancy , as GH stimulation is contraindicated in this setting Pregnancy or breastfeeding neither agent should be used during pregnancy or whilst breastfeeding

Zhang R, Packard BA, Tauchi M, DAlessio DA, Herman JP

By simultaneously engaging complementary incretin pathways, tirzepatide improves insulin sensitivity, glycemic control, and overall energy balance

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