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In these studies, patients receiving semaglutide experienced reductions in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels compared to baseline, with greater improvements observed in those achieving more substantial weight loss

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Leave-one-out analyses indicated that results were largely driven by single-study influence, reflecting the limited evidence base (Fig

14.2 Weight Reduction and Long-term Maintenance Studies in Adults with Obesity or Overweight Overview of Clinical Trials in Adults The efficacy of WEGOVY once weekly subcutaneous injection for weight reduction and long-term maintenance of body weight in conjunction with a reduced-calorie diet and increased physical activity were studied in three 68-week, randomized, double-blind, placebo-controlled trials

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