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Semaglutide also affects gastrointestinal motility more broadly, not just gastric emptying
For reference, the 232 participants in the semaglutide arm achieved an average body weight loss of 17.3%, and the 101 participants in the placebo arm achieved an average body weight loss of 2.0%
This applies to both injectable and oral GLP-1 formulations
Semaglutide Side Effects & Safety The most common side effects of semaglutide are stomach-related: nausea, diarrhea, vomiting, and constipation
Patients should contact their healthcare provider if cold intolerance is accompanied by severe fatigue, hair thinning or loss, persistent constipation, cognitive impairment, or depression , as these may indicate thyroid dysfunction requiring laboratory assessment
Primary Outcomes Participants taking semaglutide 2.4 mg weekly achieved: Average weight loss: 14.9% of body weight (compared to 2.4% in the placebo group) 86.4% lost at least 5% of body weight (vs
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