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NASH caused hepatomegaly, fibrosis, and inflammation in all mice, with aged mice showing increased heart weight, left ventricular volumes, and subtle systolic and diastolic dysfunction, thus NASH tends to worsen age-related cardiac dysfunction [37]

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162 suggested that SETD8/PR-SET7-mediated mono methylation of histone H4 at lysine 20 leads to repression of p16INK4A and ribosome-associated genes that are associated with senescence