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Interestingly, treatment with forskolin at a low concentration (0.1 M) tended to inhibit MG-induced MMP reduction and apoptosis, while high concentration (10 M) of forskolin substantially inhibited these effects ( Figures 2C, D , respectively), pointing that higher cAMP level confers the protection of mitochondria and prevention of apoptosis induced by MG

The role of glucocorticoids in the regulation of thyrotropin

The resulting inflammation and tissue damage can perpetuate the autoimmune response, creating a vicious cycle of oxidative stress and immune-mediated tissue injury [129]

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