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Wnt signaling is involved in human articular chondrocyte de-differentiation in vitro

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Studies have demonstrated that defective mitophagy is responsible for the excessive accumulation of damaged mitochondria observed in the brain regions of AD patients

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In the early stages of RA, bone marrow edema is a common finding at the spot of subchondral bone in humans, 71 and aberrant transforming growth factor- (TGF-) in the subchondral bone is involved at the onset of RA joint destruction in animal models 72 (Fig