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That is why it has an effect on tendon healing without systemic endocrine (hormonal) changes, no acromegaly-type side effects

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Systemic administration (injectable or oral), which is less common than topical use and not part of approved or standard applications, would theoretically carry different safety considerations requiring appropriate clinical evaluation, though limited research on parenteral administration in animals has suggested acceptable safety profiles at moderate doses

Med Sci Monit Int Med J Exp Clin Res 25:666674 Zhou L et al (2023) N-homocysteinylation of -synuclein promotes its aggregation and neurotoxicity

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