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A sinusoidal voltage at the 5 kHz frequency was applied to the needle electrode, whereas the low voltage probe (Tektronix TPP1000) was adopted for collecting the current flowing through the sampling resistance (R = 1 k)

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The formulation consists of the modified semaglutide compound with a concentration from 0.1 mg/ml to 25 mg/ml, and has a pH from 3.0 to 9.0

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The resulting vasculature is pain-giving, dilated, and leaky, with poor pericyte coverage, which in turn worsens hypoxia and stabilizes HIF-1 signaling in a vicious cycle (116)

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