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The combination allows researchers to explore complementary mechanisms involved in growth hormone pulsatility, metabolic regulation, and endocrine coordination

For instance, dysregulated miR-93-3p targets the PI3K/AKT signaling pathway, disrupting granulosa cell proliferation and apoptosis and ultimately arresting follicular development ( Above all, Epigenetic dysregulation in PCOSincluding DNA methylation, histone modifications, and non-coding RNA alterationsdisrupts ovarian function, hormone balance, and insulin signaling, contributing to hyperandrogenism, metabolic dysfunction, and impaired folliculogenesis

Bottom line: If you drink caffeine, keep it moderate and choose sources high in polyphenols, like coffee or tea