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In vivo findings corroborate these results: BL administration in murine peritonitis models reduces myeloperoxidase activity, suppresses secretion of pro-inflammatory cytokines (IL-1, TNF-, and IL-6), downregulates NLRP3 and IL-1 mRNA expression in peritoneal exudate cells, and decreases protein levels of phospho-p65 and mature IL-1 (Lin et al., 2019)

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Many age-related changes in circadian rhythms and sleep architecture, such as reduced rhythm amplitude, phase advance, and altered sleep consolidation, may reflect adaptive remodeling of the circadianhomeostatic system rather than intrinsic dysfunction (Scullin and Bliwise, 2015)