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89 The PK-L and PK-R subunits are transcribed from a single gene ( PKLR , for pyruvate kinase, liver, and RBC) located on chromosome 1q21, by the use of tissue-specific promoters

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The presence of furin cleavage site in diphtheria toxin (R-V-R-R ) and Pseudomonas exotoxin A (R-Q-P-R ), enhances their cytotoxic spectrum 339,340

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