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Moreover, the NP exterior is functionalized with the Msr1 antagonist fucoidan (FU), which acts as a competitive inhibitor of Msr1-mediated lipid uptake in TADCs

These findings are comforting as clinicians can now safely use these agents in patients with metabolic syndrome and those at a higher cardiovascular risk

In both trials, the most common side effect was gastrointestinal symptoms, which affected about half of the patients on either dose and about a quarter of patients on the placebo

Although individuals with obesity often exhibit greater muscle mass compared to those with normal body weight, their muscle quality is generally lower due to factors such as relative weakness and reduced mobility [15, 96]

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however, their effects on the reproductive system of patients are often overlooked, especially their impact on germ cell cytogenesis, embryonic development, and reproductive system maturation