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Melanoma in situ with multicomponent hyperpigmentation on the sole of the foot in a 65-year-old Hispanic woman

The skin is glowing, the hair is growing

Breaking that down to "per month" gives about 24 kg in the early months for many (depending on baseline bodyweight, dose, diet, exercise)

Similarly, the amplified survival benefit observed among people with established comorbiditiessuch as cardiovascular or renal diseaseis likely attributable to their higher baseline risk

Neurochem Res (2012) 37(8):16819

Tirzepatide can cause mild dehydration in early weeks, while creatine generates creatinine that kidneys must filter