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That effect is well-supported by exercise-dehydration research and is generally small under everyday conditions, but becomes more meaningful in heat, at altitude, after exercise, or during illness

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Re-establishing Homeostasis Constant exogenous stimulation of growth factors like VEGFR2 and Nitric Oxide (NO) signaling can lead to a biological plateau. The break allows the body to return to its baseline signaling levels, ensuring that the next cycle is just as effective as the first