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GLP-1 receptor agonists can stimulate GLP-1 receptors in the area postrema, a circumventricular organ in the lower brainstem that has fenestrated capillaries and can sense hormonal signals in the general circulation, and appetite centres in the hypothalamus, which has fenestrated capillaries in the median eminence

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Van Der Heide LP, Hoekman MF, Smidt MP: The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation

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