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All the members form heterodimers with small Maf proteins through leucine zipper motifs and bind to the ARE consensus sequence through basic regions, suggesting that the bZip structure of Nrf2 shares many common properties with that of other CNC members

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Furthermore, a decline in pro-inflammatory adipokines such as TNF- and resistin, alongside an elevation in adiponectin levels, contributes to enhanced metabolic flexibility and improved vascular tone (85)

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