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*Correspondence: Mariola Herbet, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Peptide Sciences In preclinical biochemical settings, inhibition of NNMT by compounds like 5-Amino-1MQ leads to alterations in intracellular NAD salvage pathways, shifts in methyl donor balance, and downstream metabolic signaling changes