Stimulated by factors such as UV exposure, pollution, smoking, and poor diet, oxidative stress increases cellular aging and promotes the development of certain diseases
Nrf2 is then translocated to the nucleus, forms heterodimers with other transcription factors such as c-Jun and small Maf proteins (G/F/K), binds to the electrophile response element (EpRE) (also known as the antioxidant response element) in the promoters of GCLC and GCLM, and regulates gene transcription
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Vitamin C, Vitamin E, and Kojic Acid Protect the Skin From Sun Damage and Free Radicals Exposure to harmful UV rays and free radicals may cause premature skin aging, dark spots, or saggy skin , among others
T.van der SchaftJ.van Os-MedendorpH.et al (2019)
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