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Anecdotal reports on forums and YouTube mention side effects like sagging skin, puffiness, or crepey texture, particularly when formulations are too strong or used too frequently

Molinoff PB, Shadiack AM, Earle D, et al

New York: Apple Academic Press (2025)

2 (2024): SJMLS VOLUME 9 , NUMBER 2, JUNE, 2024 Akinpelu Moronkeji, Frederick, O

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While some people notice a decreased appetite within the first four weeks, significant weight loss typically occurs over several months