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Aging and exercise training in skeletal muscle: Responses of glutathione and antioxidant enzyme systems

Several studies of centenarians (humans who have lived to be over 100 years old) in various countries, including Poland, Italy, and Denmark, have found very high levels of glutathione in their cells

Low levels are linked to fatigue, inflammation, and poor detox

The first step involves the binding of glutamic acid and cysteine, catalyzed by GCL, to form glutamylcysteine

28 The T h 2 response that characterizes inflammatory disease is associated with increased production of IL-4, IL-5, and IL-13

Consistent with these findings, in vivo studies in young animals indicate that glutamine availability modifies intestinal immune cell populations