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14 The number of fibroblasts measured by HSP47 expression were highest in exendin-4 treated mice as was the number of differentiated myofibroblasts which were characterized by the presence of Acta2+ cells by immunohistochemical analysis

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The article says incidence and severity vary with the rate of escalation as well as with the individual, and that slower protocols may improve tolerability

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Zhang C, Zhu X, Li L et al (2019) A small molecule inhibitor MCC950 ameliorates kidney injury in diabetic nephropathy by inhibiting NLRP3 inflammasome activation