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For the treatment groups with CuCl 2 and Cu(OAc) 2 , copper compounds had a positive correlation with the protein level regulated

Resistant cells generate more glutathione, elicit nuclear factor erythroid 2-related factor 2 (NRF2) activation, and overexpress many anti-oxidative genes such as superoxide dismutase, catalase, glutathione peroxidase, and thioredoxin reductase, providing stronger antioxidant capacity to survive in a more oxidative environment due to the sharp rise in oxidative metabolism and reactive oxygen species generation

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Both have been heralded for their effectiveness, but they operate through different mechanisms and carry distinct side effects