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Simultaneously, these bacteria-free animals have an underdeveloped intestinal mucosal immune system and systemic immunological modifications, including a marked decrease in T helper cells in the spleen

Stadtman, T

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Release of gastric inhibitory polypeptide (GIP) by intraduodenal acidification in rats and humans and abolishment of the incretin effect of acid by GIP-antiserum in rats

Clinical guidance suggests starting with manufacturer recommendations as outlined in FDA labeling, then adjusting based on individual response