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Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death

10.1016/j.humpath.2007.11.015 13 GallwitzB.GiorginoF

However, researchers suspect other biological mechanisms could also be involved

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Title: Semaglutide for Weight Loss: A Review of Clinical Trials Journal: Journal of Obesity and Metabolic Syndrome Year: 2021 Kushner, P., Cardell, B., & Rossi, A

Thus, resilience-centered thinking shifts proteostasis therapeutics from single-target correction toward network stabilization or context-specific destabilization, precisely aligned with disease biology