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This stimulation is thought to involve multiple intracellular pathways, including: Activation of phospholipase C Hydrolysis of phosphoinositides Enhanced influx of Ca ions through calcium channels In addition to promoting GH release, experimental studies suggest that GHRP-6 may also induce the secretion of other pituitary-derived hormones such as adrenocorticotropic hormone (ACTH) and prolactin in animal models