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Following activation of the GLP-1 receptor, the main signal pathway includes activation of adenylyl cyclase by stimulating G, which in turn stimulates the both the PI3K/Akt and cAMP/PKA/CREB pathways that regulate functions of various cells (136)

it's a deep lack of energy that rest doesn't fix

Here's why that combination is interesting: rapamycin inhibits mTOR, the cellular growth pathway that, when chronically overactivated, drives cellular senescence in follicle stem cell niches

In FD, mitochondrial dysfunction is a significant downstream consequence of lyso-Gb3 accumulation, which disrupts cellular homeostasis through multiple pathways [49,50,51]

This is a meaningful milestone for us, not because its flashy, but because it directly supports what were trying to build