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It creates a calorie deficit, and calorie deficits always come with some lean mass loss

That can happen

What it does is quieten what patients call food noise, the constant intrusive thoughts about food that drive snacking, second helpings, and grazing between meals

When to Consider Alternative GLP-1 Options for Mood Stability If depression emerges on semaglutide, switching to tirzepatide (which activates both GLP-1 and GIP receptors) may offer a different neurochemical profile that feels better tolerated

Barry S, Korbonits M

Many tirzepatide users benefit from Thursday or Friday injection to maximize weekend coverage