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GLP-1 receptor agonists also are recommended as first-line therapy as an alternative to metformin in patients who cannot tolerate or are contraindicated for metformin

The FDA-approved pharmaceutical version (Vyleesi) comes as an autoinjector specifically because subcutaneous injection provides optimal bioavailability, but research chemical and compounded versions offer nasal spray alternatives for those unwilling or unable to inject

24 July 2019

Liraglutide Although an older GLP-1 medication, Liraglutide is also an effective weight loss treatment option

Vlak MH, Algra A, Brandenburg R, Rinkel GJ

They also act on appetite centres in the brain, reducing hunger and food intake