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An estimated 1015% of people above 60 are believed to have this deficiency

Nicotinamide and NAD-Related Pathways By reducing the methylation of nicotinamide, NNMT inhibition may leave more nicotinamide available for salvage into NAD-related pathways

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Research highlights its potential in regulating T-cell differentiation, modulating inflammation, supporting cardiovascular function, and providing neuroprotective effects in experimental and autoimmune models

Some medications, such as metformin (used for diabetes), may affect B12 absorption rather than conversion

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