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Lancet (London) 360:219223 Burlina AP, Sershen H, Debler EA, Lajtha A (1989) Uptake of acetyl-l-carnitine in the brain

In clinical trials, 100% of healthy volunteers experienced this chromaturia with administration of 5g hydroxocobalamin with other common effects including erythema, rash (predominantly acneiform appearance) and increased blood pressure

This approach selectively targets pigmentation without causing thermal damage to surround tissues, minimizing the risk of inflammation and post-inflammatory hyperpigmentation

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The primary outcome was change in the glucose infusion rate

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