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Systolic and diastolic blood pressure improved from baseline across all groups

Several points deserve emphasis

Knowledge about cerebrovascular involvement in neurological disorders is rapidly expanding, and increasing evidence indicates that defects in angiogenesis, and the bloodbrain boundary are causally related to the cognitive dysfunctions that may be found in the course of neurodegenerative disorders (Nicolakakis and Hamel 2011

The multifunctional docking site of MET recruits to the plasma membrane stereotypical adaptor/signaling molecules such as Gab1, Grb2, SPH2, phosphoinositide-3-kinase (PI-3K), Src, phospholipase c gamma (PLC), Shc, and signal transducer and activator of transcription 3 (STAT3) (Ponzetto et al., 1994

It introduces more variables and makes it impossible to gather consistent data

DSIP enhances mitochondrial oxidative phosphorylation in the brain, which helps maintain brain function during periods of low oxygen (hypoxia)