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10.1016/j.brainres.2011.05.015 177 SunM.ChenX.YinY.-X.GaoY.ZhangL.ChenB.et al

In participants without type 2 diabetes, the highest doses (8 mg and 12 mg) were associated with mean reductions in body weight of approximately 17% at 24 weeks

This result demonstrates that ethylene regulation of smiliside A/smigliside C metabolism is dependent on the identified genetic locus and that it contributes to resistance against F

Medication timing can also make a difference

Finally, long-term consequences of NP exposure can limit clinical adoption

Acknowledgements The authors acknowledge Josephine Grist, BSc, from Costello Medical Consulting, London, UK for medical writing and editorial assistance in preparing this manuscript for publication based on the authors input and direction