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Other conditions (for example, pseudogout) which can mimic gout, should be definitively ruled out through crystal identification in joint fluid whenever possible

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Metabolic dysregulation may exacerbate immune imbalance by altering the cellular differentiation trajectories and functional states

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For instance, anti-CCP, a relatively specific biomarker, can be detected up to 10 years before the onset of RA symptoms, offering a valuable therapeutic window [150]