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A theoretical concern exists regarding use in individuals with active malignancy, based on BPC-157's capacity to stimulate growth pathways PMID: 25415472

Vitamin B12 is water-soluble, so any excess is naturally excreted by the body, reducing the risk of toxicity

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Ipamorelin is a GH secretagogue that operates on a separate receptor group than GHRH, taking after ghrelin instead

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