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McKinley WI, Rowell SE, Mansour A, Hoefer L, Polcari A, Schreiber M, Benjamin AJ

IGF1 deficiency integrates stunted growth and neurodegeneration in Down syndrome

In most studies on IGF-1 Lr3 no adverse side effects were reported with use for 4-8 weeks (per the dosage limits in the above answer) followed by 4 weeks of non-use.

Journal of trace elements in medicine and biology: organ of the Society for Minerals and Trace Elements (GMS)

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Gene expression analysis included the mechanistic target of rapamycin ( Mtor ), vascular endothelial growth factor A ( VEGFa ), protein tyrosine kinase 2 ( Pkt2 ), prostaglandin-endoperoxide synthase 2, ( Ptgs2 , cyclooxygenase (Cox) 2), and nitric oxide synthase (NOS) ( Nos1 , Nos2 , Nos3 ), commonly implicated in the injured spinal cord [73,74,75,76,77,78,79,80]