When symptoms occur, they typically relate to underlying conditions such as liver disease, kidney dysfunction, or haematological disorders that cause the elevation, rather than the high B12 itself
I don't think there are any formal guidelines in UK for the treatment of children with B12 deficiency
With respect to dosage, the average reductions were: 2000 mcg: 71.5% (single data point) 1,000 mcg: 31.8% Although limited data are available for higher dosages, the findings support the efficacy of both oral and non-oral B12 formulations in modulating homocysteine levels
It appears that long-term treatment for the moderation of the nociplastic alterations in the FM nervous system is needed
Any reputable provider should screen for cobalt allergy before administering a B12 injection
However, the finding of vascular contact must match the clinical picture and the response to therapy to confirm that this is truly the cause and to justify surgical treatment
