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In a study designed to assess whether PGN is a tumor promoter, mice were first given azoxymethane (10 mg/kg injected intraperitoneally), a genotoxic colonic carcinogen that gives rise to colon adenomas or carcinomas, and then PGN (2% in drinking water)

doi: 10.1111/j.1439-0272.2007.00794.x 208 MoazzamASharmaRAgarwalA

However, unless clinical trial data do not become available, the approach will be devoid of a scientific endorsement and could continue to be the less-preferred therapeutic target for AD

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The role of dopamine in obsessive-compulsive disorder: preclinical and clinical evidence

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