Trials are still small, but initial results indicate quantifiable effects on stress markers and patient-reported improvement
The stakes are even higher
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H&E staining results further confirmed that the aortic wall thickness of mice treated with FOXO4-DRI was significantly thinner, and ultrasound examination results showed that the PWV of the aorta was slowed down after FOXO4-DRI treatment, indicating better vascular elasticity and significantly improved vascular function compared to the control group (Figures 2D,E)
Advances in single-cell transcriptomics, epigenomics, and spatial transcriptomics have delineated marked -cell heterogeneity, revealing subpopulations with differential secretory capacity, stress resilience, and vulnerability to metabolic and immune-mediated insults
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