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doi: 10.1016/S1262-3636(17)30070-8 196 DongZZhuangQYeXNingMWuSLuLet al

The Gq pathway begins with the coupling to phospholipase C (PLC), which converts phosphatidylinositol 4,5-bisphosphate (PIP2) into inositol trisphosphate (IP3) and diacylglycerol (DAG)

Increased cellular damage has been closely linked to cardiovascular diseases, cancer, and certain neurodegenerative conditions

However, these guidelines largely focused on hydrochlorothiazide, not chlorthalidone or other thiazide-like drugs like indapamide (Stafford et al., 2010

Injury to the hippocampus is one of the post-SE manifestations that disturb various cerebral functions leading to memory and learning impairment (60)

However, across many checkpoint-focused AD studies that primarily target oxidative stress, A clearance, or neuroinflammatory checkpoints, the field has only rarely measured a complete ferroptosis signaturethat is, simultaneous assessment of iron-dependent lipid peroxidation together with GPX4/SLC7A11 and ACSL4/LPCAT3 alterations, combined with ferroptosis-selective rescue experiments (e.g., ferrostatin-1, liproxstatin-1, or FSP1 activation)