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In comparative studies, Tirzepatide has shown a "GIP-heavy" bias, which many researchers suspect is the reason for its superior tolerability compared to high-dose GLP-1 monotherapies

In addition, increased C-peptide levels and better glycemic control during the year of observation were noted ( 4.2.2 RCTs In RCTs, insulin dose reductions were observed with the addition of GLP-1RA ( Table 1 )

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It has been noted that the primary weight reduction effects of GLP-1 RAs may be attributed to neurobiological appetite suppression and subsequent reduced energy intake