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FasL binding induces the trimerization of Fas, which recruits the adaptor protein FADD (Fas-associated death domain) and the initiator caspase-8 or caspase-10, which are oligomerized and activated through autocatalysis

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NICE technology appraisal guidance and the MHRA/EMC SmPC recommend that Wegovy should be combined with a reduced-calorie diet and increased physical activity