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An analysis of the free energy minima and maxima for the water probe in subpockets A-C using SZMAP 37 and WaterOrientation extension in VIDA 40 is shown in Fig

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In experimental models of inflammatory bowel disease and intestinal injury, the peptide consistently improves mucosal integrity, reduces local and systemic inflammatory mediators, and counters damage induced by stressors such as NSAIDs, alcohol, and other toxic agents