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However, for those with a BMI 40 or BMI 35 with obesity-related comorbidities, GLP-1 agonists alone often do not provide the degree of weight loss required for disease control or resolution

Body areas with hyperpigmentation, such as elbows and knees

Gallbladder disorders: In the STEP 1 trial found a higher incidence of gallbladder-related events, such as gallstones or cholecystitis, was found in the semaglutide group than the placebo group

Davies, K.J., A.T

This goes beyond simple wound closure to actual functional restoration

It increases the risk of: Muscle Loss (Sarcopenia): If you lose weight too fast, your body will catabolize muscle tissue