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doi: 10.1016/j.schres.2022.12.005 118 YuHNiPTianYZhaoLLiMLiXet al

Muscle-liver trafficking of BCAA-derived nitrogen underlies obesity-related glycine depletion

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While mTORC1 is a key signaling node that integrates multiple environmental signals to modulate protein (e.g., GPX4) synthesis, and its inactivation reduces GPX4 and sensitizes tumor cells to ferroptosis